August 18

Sinemet – Info

SINEMET®
(carbidopa levodopa) Tablets
Brand Names: Atamet, Parcopa, Sinemet, Sinemet CR
Generic Name: carbidopa and levodopa (Pronunciation: KAR bi DOE pa and LEE voe DOE pa)

DESCRIPTION

SINEMET® (carbidopa levodopa) is a combination of carbidopa and levodopa for the treatment of Parkinson’s disease and syndrome.

Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 244.3. It is designated chemically as (-)-L-α- hydrazino-α-methyl-β-(3,4-dihydroxybenzene) propanoic acid monohydrate. Its empirical formula is C10H14N2O4•H2O, and its structural formula is:

Carbidopa - Structural Formula Illustration

Tablet content is expressed in terms of anhydrous carbidopa which has a molecular weight of 226.3.

Levodopa, an aromatic amino acid, is a white, crystalline compound, slightly soluble in water, with a molecular weight of 197.2. It is designated chemically as (—)-L-α-amino-β-(3,4-dihydroxybenzene) propanoic acid. Its empirical formula is C9H11NO4, and its structural formula is:

Levodopa - Structural Formula Illustration

SINEMET is supplied as tablets in three strengths:

SINEMET 25-100, containing 25 mg of carbidopa and 100 mg of levodopa.

SINEMET 10-100, containing 10 mg of carbidopa and 100 mg of levodopa.

SINEMET 25-250, containing 25 mg of carbidopa and 250 mg of levodopa.

Inactive ingredients are hydroxypropyl cellulose, pregelatinized starch, crospovidone, microcrystalline cellulose, and magnesium stearate. SINEMET 10-100 and 25-250 Tablets also contain FD&C Blue #2/Indigo Carmine AL. SINEMET 25-100 Tablets also contain D&C Yellow #10 Lake.

What is the drug Sinemet used for?
It may also be used for other conditions as determined by your doctor. Sinemet is an antidyskinetic combination. Levodopa is transformed by the body and the brain into a substance that helps to decrease tremors and other symptoms of Parkinson disease. Carbidopa helps levodopa to reach the brain.

What does Sinemet treat?
This combination medication is used to treat symptoms of Parkinson’s disease or Parkinson-like symptoms (such as shakiness, stiffness, difficulty moving). Parkinson’s disease is thought to be caused by too little of a naturally occurring substance (dopamine) in the brain.

What are the side effects of the drug Sinemet?
Less serious side effects may include:
mild nausea, dry mouth, loss of appetite, heartburn, diarrhea, constipation;
headache, dizziness, drowsiness, blurred vision;
sneezing, stuffy nose, cough, or other cold symptoms;
sleep problems (insomnia), strange dreams;
muscle pain, numbness or tingly feeling;

What does Sinemet do for Parkinson’s?
Sinemet (Levodopa/Carbidopa) Levodopa (also called L-dopa) is the most commonly prescribed and most effective drug for controlling the symptoms of Parkinson’s disease, particularly bradykinesia and rigidity. Levodopa is transported to the nerve cells in the brain that produce dopamine.

Why are levodopa and carbidopa given together?
The drug levodopa is synthesized in the brain into dopamine. It is the most important first-line drug for the management of Parkinson’s. Levodopa is almost always given in combination with the drug carbidopa, which prevents the nausea that can be caused by levodopa alone.

How does Ldopa work?
Carbidopa-levodopa is used in the treatment of Parkinson’s disease. Parkinson’s disease is believed to be caused by low levels of dopamine in certain parts of the brain. When levodopa is taken orally, it crosses into the brain through the “blood- brain barrier.” Once it crosses, it is converted to dopamine.

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